A nurse is working in a well-child clinic administering immunizations to preschoolers. The nurse should do which procedure to minimize local reactions to the biological drugs? 1. Apply EMLA cream 1 hour before. 2. Change the needle on the syringe after drawing up the biological drug. 3. Inject into the vastus lateralis or ventrogluteal muscle. 4. Use distraction such as telling the child to hold the breath.